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Effect of Remote Ischaemic Conditioning on clinical outcomes in ST-segment elevation myocardial infarction patients undergoing Primary Percutaneous Coronary Intervention (ERIC-PPCI)

A multicentre randomised controlled clinical trial.

Aim: To determine whether remote ischaemic conditioning (RIC) improves clinical outcomes in STEMI patients undergoing PPCI.

Primary Endpoint: To investigate whether RIC reduces the combined primary endpoint rate of cardiac death and hospitalisation for heart failure (HHF) at 12 months in STEMI patients undergoing PPCI.

Secondary Endpoints:

To investigate whether RIC can affect the following secondary endpoints below:

  1. Rates of cardiac death and HHF at 30 days. This data will be collected at the clinical follow up outpatient
    appointment (at 6-8 weeks post-PPCI).
  2. Rates of all-cause death, repeat coronary revascularisation, reinfarction, stroke at 30 days and 12 months.
    This data will be collected at the clinical follow up outpatient appointment (at 6-8 weeks and one year
    post-PPCI).
  3. TIMI flow post PPCI28
  4. Quality of life at 6-8 weeks and 12 months (EuroQol EQ-5D-5L)

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