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Effect of Remote Ischaemic Conditioning on clinical outcomes in ST-segment elevation myocardial infarction patients undergoing Primary Percutaneous Coronary Intervention (ERIC-PPCI)
A multicentre randomised controlled clinical trial.
Aim: To determine whether remote ischaemic conditioning (RIC) improves clinical outcomes in STEMI patients undergoing PPCI.
Primary Endpoint: To investigate whether RIC reduces the combined primary endpoint rate of cardiac death and hospitalisation for heart failure (HHF) at 12 months in STEMI patients undergoing PPCI.
Secondary Endpoints:
To investigate whether RIC can affect the following secondary endpoints below:
- Rates of cardiac death and HHF at 30 days. This data will be collected at the clinical follow up outpatient
appointment (at 6-8 weeks post-PPCI). - Rates of all-cause death, repeat coronary revascularisation, reinfarction, stroke at 30 days and 12 months.
This data will be collected at the clinical follow up outpatient appointment (at 6-8 weeks and one year
post-PPCI). - TIMI flow post PPCI28
- Quality of life at 6-8 weeks and 12 months (EuroQol EQ-5D-5L)